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Tohoku University Technology: Urinary toxin reducer with sesamol: T20-695

Sesamol inhibits enzymes produced by intestinal bacteria

Phenyl sulfate(PS) and indoxyl sulfuric(IS) are factor of Diabetic nephropathy(DN). These compounds are produced by the reaction of phenol and indole which are protein metabolites, with tyrosine phenol lyase and tryptophan indole lyase which intestinal bacteria have. Decreasing PS and IS in blood is important for DN treatment.   In the present study, certain sesame-derived lignans exhibited TPL and TIL inhibitory activity.

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